Clinical, molecular and microbial characterisation of the eosinophilic endotype of bronchiectasis: data from the EMBARC-BRIDGE study
LC-MS/MS can detect eosinophilic inflammation within bronchiectasis sputum. Weak associations between elevated airway eosinophil proteins, bronchiectasis severity and <i>P. aeruginosa</i> infection were observed. Direct measurement of eosinophilic airway inflammation provides additional information in addition to BECs. Eosinophilic bronchiectasis associated with <i>P. aeruginosa</i> infection and <i>Aspergillus</i> sensitisation.
Authors
- Michal Shteinberg (ORCID: https://orcid.org/0000-0002-0432-3398)
- E Polverino
- Elena Kuzmanova
- Pieter Goeminne (ORCID: https://orcid.org/0000-0001-6220-2220)
- Natalie Lorent (ORCID: https://orcid.org/0000-0002-2653-5885)
- Amelia Shoemark (ORCID: https://orcid.org/0000-0001-7360-6060)
- S H Chotirmall
- Clare Clarke
- Hollian Richardson
- Oriol Sibila
- Merete Bridget Long
- Jeffrey T. J. Huang
- Stefano Aliberti
- James Chalmers
- Felix C Ringshausen
- Charles Haworth
- Daniela Alferes de Lima
- Jennifer Pollock
- Morven Shuttleworth
- Michael Loebinger
- Eva Rodriguez-Suarez
Institutions
- Humanitas University (IT)
- University of Ulster (GB)
- Nanyang Technological University (SG)
- Technion – Israel Institute of Technology (IL)
- University of Dundee (GB)
- Royal Papworth Hospital (GB)
- Tan Tock Seng Hospital (SG)
- University of Oxford (GB)
- Royal Brompton Hospital (GB)
- Carmel Medical Center (IL)
- Hospital Clínic de Barcelona (ES)
- Vlaamse Vereniging voor Obstetrie en Gynaecolo (BE)
- Vall d'Hebron Hospital Universitari (ES)
- German Center for Lung Research (DE)
- Royal Victoria Hospital (GB)
- AstraZeneca (Finland) (FI)
- AstraZeneca (United States) (US)
- IRCCS Humanitas Research Hospital (IT)
- Imperial College London (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Thorax
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1136/thorax-2025-223305
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Teva Pharmaceutical Industries
- Chiesi Farmaceutici
- CSL Behring
- European Respiratory Society
- Deutsches Zentrum für Infektionsforschung
- LifeArc
- European Federation of Pharmaceutical Industries and Associations
- MannKind Corporation
- INOVIO Pharmaceuticals
- Moderna
- Insmed
- Asthma and Lung UK
- European Commission
- National Research Foundation
- National Research Foundation Singapore
- Deutsches Zentrum für Lungenforschung
- Imam Abdulrahman Bin Faisal University
- Grifols
- Medical Research Council
- National Medical Research Council