TIPE2 knockdown enhances the anti-tumor efficacy of NKG2D CAR-T cells against pancreatic cancer via activating NF-κb signaling pathway
We successfully developed TIPE2-downregulated NKG2D-CAR-T cells that exhibited enhanced activation and cytotoxicity while limiting apoptosis and exhaustion against NKG2D ligand-expressing pancreatic tumors, highlighting TIPE2 as a promising intracellular immune checkpoint target for optimizing CAR-T cell therapy in solid tumors.
Authors
- Iqra Ajmal (ORCID: https://orcid.org/0000-0002-5239-3972)
- Muhammad Asad Farooq (ORCID: https://orcid.org/0000-0002-8792-4171)
- Bingtan Du
- Wenzheng Jiang
- Ying Zhou
Institutions
- East China Normal University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1186/s12967-026-07831-w
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00