Nanostructured lipid carrier-mediated delivery of donepezil attenuates neuropathic pain via central cholinergic receptor modulation
Intranasal DPZ-NLCs show promise as a therapeutic strategy for NP, likely involving central M2 mAChR- and α7 nAChR-dependent mechanisms. Limitations include the use of male mice only and the absence of pharmacokinetic assessments.
Authors
- Flávio P. Veras (ORCID: https://orcid.org/0000-0002-6222-4064)
- Angel Roberto Barchuk (ORCID: https://orcid.org/0000-0001-8417-2763)
- Giovane Souza Galdino
- Isabelly Fernanda Ferraz de Souza (ORCID: https://orcid.org/0000-0003-2955-9724)
- Rafaela Silva dos Santos (ORCID: https://orcid.org/0000-0003-2287-2726)
- Fernanda Santos Rocha
- João Paulo Prado
- Ester Siqueira Caixeta
- Bruno Zavan
- Gislaine Ribeiro Pereira
- Albená Nunes-Silva
- Rayner Ribeiro Cardoso
- Thiago Roberto Lima Romero
Institutions
- Universidade Federal de Ouro Preto (BR)
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal de Alfenas (BR)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1093/jpp/rgag003
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00