Minor trauma-induced eccrine porocarcinoma of the toe in a patient on long-term carbamazepine: a case report and literature review

This case highlights the importance of considering rare malignancies like Eccrine Porocarcinoma in the differential diagnosis of non-healing acral ulcers. An early biopsy is crucial. The long-term use of carbamazepine in this context is noted, and its potential role as a co-factor in tumor development, possibly interacting with local chronic inflammation, is discussed. Further investigation into the influence of systemic medications on the pathogenesis of such rare tumors is warranted.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-02-13
DOI
https://doi.org/10.3389/fonc.2026.1727762
Primary Topic
Cancer and Skin Lesions
Type
article
Field-Weighted Citation Impact
0.00

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article

Minor trauma-induced eccrine porocarcinoma of the toe in a patient on long-term carbamazepine: a case report and literature review

Jiabin Lin, Yifan Wang, Xinyu Zhao, Jinghang Lv et al.
Frontiers in Oncology
Cancer and Skin Lesions
article

Minor trauma-induced eccrine porocarcinoma of the toe in a patient on long-term carbamazepine: a case report and literature review

Jiabin Lin, Yifan Wang, Xinyu Zhao, Jinghang Lv, Haidong Liang, Lianbo Yang, Xinyao Cui, Ziang Zheng
article en

Abstract

This case highlights the importance of considering rare malignancies like Eccrine Porocarcinoma in the differential diagnosis of non-healing acral ulcers. An early biopsy is crucial. The long-term use of carbamazepine in this context is noted, and its potential role as a co-factor in tumor development, possibly interacting with local chronic inflammation, is discussed. Further investigation into the influence of systemic medications on the pathogenesis of such rare tumors is warranted.

Frontiers in OncologyVol. 16
Dalian Medical University (CN), Second Affiliated Hospital of Dalian Medical University (CN)
Dalian Medical University
Good health and well-being
Openalex Percentile: Top 54%
Cancer and Skin Lesions
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