Pyridine Synthesis via [3 + 2 + 1] Oxidative Cyclization of Enamines, Ethyl Tertiary Amines, and Alcohols: Copper-Catalyzed Cascade Multicomponent Poly C(sp <sup>3</sup> )–H Functionalization
A copper-catalyzed [3 + 2 + 1] oxidative cyclization to access functionalized pyridines was descripted. Employing ethyl tertiary amine as a C2 source, alcohol as a C1 source, and easily handled enamines, one new C-N bond and two new C-C bonds are sequentially constructed by the effective functionalization of multiple C(sp<sup>3</sup>)-H bonds. Besides the readily available raw materials, mild reaction conditions, broad substrate scope, and effective bond-forming strategy, the present approach offers a viable strategy for preparing functionalized pyridines in future organic synthesis.
Authors
- Zijing Bai
- Peng Gao (ORCID: https://orcid.org/0009-0001-6814-505X)
- Jingzhi Cheng
- Binghan Du
- Yutong He (ORCID: https://orcid.org/0000-0002-5588-622X)
- Wei Shi (ORCID: https://orcid.org/0009-0004-7574-2735)
- Chengli Deng
- Ruimin He
Institutions
- Baoji University of Arts and Sciences (CN)
- Institute of Organic Chemistry with Centre of Phytochemistry (BG)
- Yuxi Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1021/acs.orglett.6c00130
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00