Identification of mitochondrial-related subtypes and development of a prognostic model for pancreatic ductal adenocarcinoma

This study established a significant link between mitochondrial dysfunction and PDAC molecular subtypes, immune microenvironment remodeling, and clinical prognosis. The developed seven-MitoRG signature and nomogram could serve as reliable prognostic tools. These findings provide insights into the role of mitochondria in the pathogenesis of PDAC and offer potential targets for developing personalized therapeutic strategies.