Comparative effects of intermittent theta-burst stimulation and sequential bilateral rTMS on depression and emotion regulation in major depressive disorder: a randomized controlled trial
Intermittent theta-burst stimulation targeting the left dorsolateral prefrontal cortex induces more pronounced improvements in depressive symptoms and cognitive reappraisal than sequential bilateral rTMS, likely associated with potentiation of left prefrontal emotion-regulatory circuits. Sequential bilateral rTMS also provides therapeutic benefit, possibly through restoring interhemispheric balance.
Authors
- Guojian Yan (ORCID: https://orcid.org/0000-0002-3928-0121)
- Chaoli Deng
- Zhengzhi Deng
- Jiang Wu
- Zhihong Chen
- Hongmei Yan
- Anran Hu
- Yaqin Li
- Dezhong Yao
- Li Pu
Institutions
- The Fourth People's Hospital (CN)
- Fourth People's Hospital of Sichuan Province (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fnins.2026.1756383
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project