A Whole-body Cooling Strategy in Uncontrolled Donation After Circulatory Death: Insights From a Porcine Ex Vivo Lung Perfusion Model
This novel cooling approach effectively reduced lung temperature during warm ischemia, resulting in improved lung function during EVLP. These data suggest that this method could mitigate ischemia-reperfusion injury in uDCD donors, expanding the donor lung pool.
Authors
- Kenneth R. McCurry (ORCID: https://orcid.org/0000-0003-2512-992X)
- Tetsuhito Kigata (ORCID: https://orcid.org/0000-0002-2219-9634)
- Toshihiro Okamoto (ORCID: https://orcid.org/0000-0002-8777-0467)
- Daisuke SAKOTA
- Hiromichi Niikawa (ORCID: https://orcid.org/0000-0001-7761-6637)
- Ichiro Sakanoue (ORCID: https://orcid.org/0000-0003-3903-6441)
- Carol Farver (ORCID: https://orcid.org/0000-0002-8055-8252)
- Yoshinori Okada
- Ryo Kosaka
- Soumei Baba
Institutions
- Tokyo Medical and Dental University (JP)
- Cleveland Clinic (US)
- Tohoku University (JP)
- Kyoto University (JP)
- Cleveland Clinic Lerner College of Medicine (US)
- Tohoku Medical and Pharmaceutical University Hospital (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- Tohoku Medical and Pharmaceutical University (JP)
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1097/txd.0000000000001904
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00