Association of geriatric nutritional risk index with metabolic dysfunction-associated steatotic liver disease and subtypes in Chinese elderly: identification of an overnutrition risk threshold and implications for extended risk stratification

Elevated GNRI significantly increases MASLD and subtype risks in Chinese elderly, with GNRI ≥107.59 identified as a critical threshold for escalating the risk of MASLD. These findings support extending GNRI's risk stratification to overnutrition monitoring, enabling prioritized screening for metabolic hazards. Future research should validate this threshold's clinical utility, establish evidence-based upper limits for overnutrition risk, and explore GNRI's role in MASLD pathogenesis.

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Publication Details

Journal
Frontiers in Nutrition
Published
2026-02-13
DOI
https://doi.org/10.3389/fnut.2026.1743679
Primary Topic
Nutrition and Health in Aging
Type
article
Field-Weighted Citation Impact
0.00

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article

Association of geriatric nutritional risk index with metabolic dysfunction-associated steatotic liver disease and subtypes in Chinese elderly: identification of an overnutrition risk threshold and implications for extended risk stratification

Qiuyun Kang, Mingxin Guo, Tianran Shen, Haiyan Chen et al.
Frontiers in Nutrition
Nutrition and Health in Aging
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Association of geriatric nutritional risk index with metabolic dysfunction-associated steatotic liver disease and subtypes in Chinese elderly: identification of an overnutrition risk threshold and implications for extended risk stratification

Qiuyun Kang, Mingxin Guo, Tianran Shen, Haiyan Chen, Haixin Lyu, Zegeng Zhan, Yangyang Qin, Lifang Mao
article en

Abstract

Elevated GNRI significantly increases MASLD and subtype risks in Chinese elderly, with GNRI ≥107.59 identified as a critical threshold for escalating the risk of MASLD. These findings support extending GNRI's risk stratification to overnutrition monitoring, enabling prioritized screening for metabolic hazards. Future research should validate this threshold's clinical utility, establish evidence-based upper limits for overnutrition risk, and explore GNRI's role in MASLD pathogenesis.

Frontiers in NutritionVol. 13
Guangdong Pharmaceutical University (CN)
National Natural Science Foundation of China
Zero hunger
Openalex Percentile: Top 54%
Nutrition and Health in Aging
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