Soluble ST2 drives fulminant myocarditis progression via the IGF2R–YY1 mitochondrial axis
sST2 drives FM by disrupting cardiomyocyte mitochondrial homeostasis independently of IL-33 and represents both a clinically prognostic biomarker and a therapeutic target.
Authors
- Xiaoquan Rao
- Donghui Zhang (ORCID: https://orcid.org/0000-0002-6208-6984)
- Zheng Wen (ORCID: https://orcid.org/0000-0002-9404-8800)
- Huihui Li (ORCID: https://orcid.org/0000-0003-0511-1693)
- Yan Zhuang (ORCID: https://orcid.org/0000-0003-3483-0988)
- Kudusi Abuduwufuer
- Chen Chen
- Zhuo Zhang
Institutions
- Goethe University Frankfurt (DE)
- Frankfurt Institute for Advanced Studies (DE)
- Wuhan Union Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1093/eurheartj/ehag105
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 30.07