216. Effect of beethoven music intervention on cognitive function and emotional stability IN patients with schizophrenia

Abstract Background Patients with schizophrenia commonly experience cognitive dysfunction and emotional dysregulation, which severely affect their social functioning and quality of life. Traditional pharmacological treatments have limited efficacy in improving these symptoms, highlighting an urgent need to explore safe and effective non-pharmacological adjunctive interventions. Music intervention, as a potential therapy, shows promise in improving mood and cognition. However, existing research primarily focuses on general or relaxing music, lacking in-depth exploration of structured music by specific composers. Given the rigorous structure, rich emotional expression, and potential neuromodulatory effects of Beethoven's music, this study aims to systematically evaluate its efficacy as a structured auditory stimulus for improving cognitive function and emotional stability in patients with schizophrenia, thereby providing new evidence-based insights for clinical rehabilitation. Methods The study employed a randomized controlled trial design. Eighty inpatients with schizophrenia meeting the ICD-10 diagnostic criteria were recruited and randomly assigned to an experimental group (n = 40) and a control group (n = 40). Both groups maintained their routine antipsychotic medication. The experimental group received an 8-week Beethoven music intervention, administered 5 times per week for 30 minutes each session. The intervention playlist, curated by experts, primarily featured sonatas and symphony movements characterized by clear structure and rich emotional expression. The control group listened to neutral white noise for the same duration. At three time points—before intervention, at the end of the 4th week, and at the end of the 8th week (post-intervention)—cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to evaluate overall cognition and subdomains such as attention and memory. Emotion-related symptoms were assessed using the negative symptom subscale and the anxiety/depression items from the Positive and Negative Syndrome Scale (PANSS). All assessments were conducted by professionals blinded to group assignment. Results After 8 weeks of intervention, between-group comparisons revealed that the experimental group scored significantly higher than the control group on the RBANS total score (t = 3.21, p<.01) and on the subscales of immediate memory (t = 2.87, p<.05) and attention (t = 2.45, p<.05). Regarding emotional symptoms, the experimental group showed a significantly greater reduction than the control group in PANSS negative symptom scores (t = 2.68, p<.05) and anxiety/depression item scores (t = 3.05, p<.01), indicating clear improvement in both cognition and mood. Time-trend analysis further indicated that cognitive and emotional improvements in the experimental group began to emerge from the 4th week and strengthened with continued intervention (Ftime×group = 6.34, p<.05), while changes in the control group were not significant. Discussion The study demonstrates that an 8-week Beethoven music intervention can effectively improve overall cognitive function in patients with schizophrenia, particularly in memory and attention, while also helping to stabilize mood and alleviate negative and anxiety/depression symptoms. The results suggest that structured classical music may activate neural networks associated with cognitive control and emotional regulation through its regular acoustic properties. Future research should further explore different music genres, intervention durations, and neurobiological mechanisms to optimize music intervention protocols and promote their clinical translation in psychiatric rehabilitation.