Proximity extension assay-based targeted proteomics for biomarker discovery in adult bacterial infections
Current applications of PEA-based proteomics in adult bacterial infections is limited and largely exploratory. Rather than supporting immediate clinical translation, the available evidence suggests the value of PEA-based approaches for informing biomarker discovery. Future research should prioritize well-designed, longitudinal, and pathogen-stratified studies in clinically relevant settings to strengthen evidence robustness and support the rational development of proteomics-informed diagnostic and translational strategies.
Authors
- Enrico Sguazzini (ORCID: https://orcid.org/0009-0007-8547-1467)
- Francesco Petri (ORCID: https://orcid.org/0000-0003-0125-9551)
- Tarek Nayfeh (ORCID: https://orcid.org/0000-0001-9052-5537)
- C. Banfi
- Marta Colaneri (ORCID: https://orcid.org/0000-0002-5939-9576)
- Carlo Montagna
- Martina Offer
- Matteo Passerini
- Andrea Gori
- Cecilia Bonazzetti
Institutions
- University of Milan (IT)
- Luigi Sacco Hospital (IT)
- Centro Cardiologico Monzino (IT)
- Evidence Based Research (United States) (US)
- Centre for Multidisciplinary Research in Health Science (IT)
- Mayo Clinic in Florida (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- ASST Fatebenefratelli Sacco (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fcimb.2026.1716483
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 0.00