Elderly kidney transplant recipients: efficacy and risks of a conservative immunosuppression regimen

Despite receiving lower mycophenolate doses and fewer corticosteroids along with a higher tacrolimus level-to-dose ratio, seniors had more adverse events. However, graft survival was not affected. These results suggest that elderly patients may benefit from reduced immunosuppressant exposure, supporting a conservative approach.

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Publication Details

Journal
Brazilian Journal of Nephrology
Published
2026-02-13
DOI
https://doi.org/10.1590/2175-8239-jbn-2025-0068en
Primary Topic
Renal Transplantation Outcomes and Treatments
Type
article
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article

Elderly kidney transplant recipients: efficacy and risks of a conservative immunosuppression regimen

Rafael Ximenes Oliveira, Paula Frassinetti Castelo Branco Camurça Fernandes, Janaína de Almeida Mota Ramalho, Raoni de Oliveira Domingues-da-Silva et al.
Brazilian Journal of Nephrology
Renal Transplantation Outcomes and Treatments
article

Elderly kidney transplant recipients: efficacy and risks of a conservative immunosuppression regimen

Rafael Ximenes Oliveira, Paula Frassinetti Castelo Branco Camurça Fernandes, Janaína de Almeida Mota Ramalho, Raoni de Oliveira Domingues-da-Silva, A. Alcántara, Sônia Leite da Silva, Claudia Maria Costa de Oliveira, Isvi Brandão Araújo
article en

Abstract

Despite receiving lower mycophenolate doses and fewer corticosteroids along with a higher tacrolimus level-to-dose ratio, seniors had more adverse events. However, graft survival was not affected. These results suggest that elderly patients may benefit from reduced immunosuppressant exposure, supporting a conservative approach.

Brazilian Journal of NephrologyVol. 48(2)
Universidade Estadual do Ceará (BR), Universidade Federal do Ceará (BR), Universidade de Fortaleza (BR)
Good health and well-being
Openalex Percentile: Top 55%
Renal Transplantation Outcomes and Treatments
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Elderly kidney transplant recipients: efficacy and risks of a conservative immunosuppression regimen — Rafael Ximenes Oliveira, Paula Frassinetti Castelo Branco Camurça Fernandes, et al. · Brazilian Journal of Nephrology (2026) | TGRS Research Map | TGRS