Integrated Germline and Somatic Molecular Profiling to Detect Cancer Predisposition Has a High Clinical Impact in Poor-Prognosis Pediatric Cancer
Our findings establish the clinical benefit and feasibility of integrated tumor-germline whole genome screening to detect GPV in children with poor-prognosis cancers and their first-degree relatives.
Authors
- Pamela Ajuyah (ORCID: https://orcid.org/0000-0002-5529-1461)
- M. Haber
- Geoffrey McCowage (ORCID: https://orcid.org/0000-0003-3471-8443)
- P. Downie
- Noemi Fuentes-Bolanos
- Nicholas G. Gottardo (ORCID: https://orcid.org/0000-0002-1082-6776)
- Marion K. Mateos (ORCID: https://orcid.org/0000-0002-2763-5853)
- Cathy Kiraly‐Borri (ORCID: https://orcid.org/0000-0003-1711-8390)
- Paulette Barahona (ORCID: https://orcid.org/0000-0002-3184-8499)
- Alexandra Sherstyuk (ORCID: https://orcid.org/0000-0001-9965-8002)
- Jordan R. Hansford (ORCID: https://orcid.org/0000-0001-7733-383X)
- Luciano Dalla‐Pozza (ORCID: https://orcid.org/0000-0001-6826-764X)
- Andrew S. Moore (ORCID: https://orcid.org/0000-0001-8062-1779)
- Marie Wong (ORCID: https://orcid.org/0000-0003-0066-6606)
- Frank Alvaro
- Sam El-Kamand (ORCID: https://orcid.org/0000-0003-2270-8088)
- Hetal Dholaria (ORCID: https://orcid.org/0000-0003-1713-3822)
- David S. Ziegler (ORCID: https://orcid.org/0000-0001-7451-7916)
- Heather Tapp
- Chelsea Mayoh (ORCID: https://orcid.org/0000-0002-6398-3046)
- Bhavna Padhye (ORCID: https://orcid.org/0000-0003-0740-3606)
- Dong-Anh Khuong-Quang (ORCID: https://orcid.org/0000-0001-6305-7790)
- Eliza Courtney (ORCID: https://orcid.org/0000-0003-1017-0372)
- Antoinette Catherine Anazodo (ORCID: https://orcid.org/0000-0002-5495-6062)
- Kanika Bhatia
- Ann-Kristin Alteköester (ORCID: https://orcid.org/0000-0002-0593-2785)
- Vanessa Tyrrell (ORCID: https://orcid.org/0000-0002-5162-517X)
- Mark Pinese
- Helen Marfan
- Mark J. Cowley (ORCID: https://orcid.org/0000-0002-9519-5714)
- Lisette Curnow
- Meera Warby (ORCID: https://orcid.org/0000-0002-1702-9198)
- Paul G. Ekert (ORCID: https://orcid.org/0000-0002-2976-8617)
- Wayne Nicholls (ORCID: https://orcid.org/0000-0003-0926-526X)
- Ashleigh Sullivan (ORCID: https://orcid.org/0000-0002-7040-2414)
- Sheena Nunag
- Rozanna Alli
- G M Marshall
- Loretta MS Lau
- Judy Kirk
- Sarah O'Sullivan
- Paul J. Wood
- Sarah Josephi-Taylor
- Katherine Tucker
- Nicola Poplawski
- Naomi Warren
- Toby N. Trahair
- Seong-Lin Khaw
Institutions
- Broad Institute (US)
- The University of Sydney (AU)
- Royal Adelaide Hospital (AU)
- Royal Children's Hospital (AU)
- The Kids Research Institute Australia (AU)
- The University of Western Australia (AU)
- Royal Brisbane and Women's Hospital (AU)
- Princess Margaret Hospital for Children (AU)
- Peter MacCallum Cancer Centre (AU)
- Women's and Children's Hospital (AU)
- King Edward Memorial Hospital (AU)
- Children's Hospital at Westmead (AU)
- Hudson Institute of Medical Research (AU)
- Westmead Hospital (AU)
- UNSW Sydney (AU)
- Children’s Health Queensland Hospital and Health Service (AU)
- Monash Children’s Hospital (AU)
- Prince of Wales Hospital (AU)
- Victorian Clinical Genetics Services (AU)
- Children's Cancer Institute Australia (AU)
- Sydney Children's Hospital (AU)
- Westmead Institute (AU)
- South Australian Health and Medical Research Institute (AU)
- John Hunter Children's Hospital (AU)
- Westmead Institute for Medical Research (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-3806
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00