Strategies for Monitoring Serum Protein Degradation With an Antibody Array‐Based Technology
Our data demonstrate the feasibility of employing antibody arrays for detecting serum protein degradation. Using this platform, we found some serum proteins with clinical significance rapidly degrade at room temperature, including interleukins (e.g., IL-1β/IL-12p40/IL-17), growth factors (e.g., aFGF, bFGF, and BMP-2), and chemokines (e.g., I-309, 6Ckine, and BLC). These may serve as potential biomarkers for assessing human serum sample quality.
Authors
- Yingqing Mao (ORCID: https://orcid.org/0009-0008-1133-0052)
- Yanlin Wang (ORCID: https://orcid.org/0000-0002-6183-2914)
- Hua Dong (ORCID: https://orcid.org/0000-0001-9362-2236)
- Wei Huang (ORCID: https://orcid.org/0000-0002-7279-0932)
- Shuhong Luo
- Min Lang
- Siwei Zhu
Institutions
- Biocure (United States) (US)
- RayBiotech (China) (CN)
- Zhujiang Hospital (CN)
- South China Institute Of Environmental Sciences (CN)
- Guangzhou Medical University Cancer Hospital (CN)
- CSSC Offshore & Marine Engineering Company (China) (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Clinical Laboratory Analysis
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1002/jcla.70173
- Primary Topic
- Advanced Biosensing Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00