Unravelling the role of inflammatory markers in coronary artery disease risk via association, mediation and prediction analyses
Inflammatory markers captured by routine test were consistently associated with future CAD, suggesting that part of CAD risk is reflected in low-cost hematologic parameters. An integrated IRS showed modest but statistically significant improvement in risk discrimination, but external validation and clinical impact studies are needed before implementation.
Authors
- Yan Xu (ORCID: https://orcid.org/0000-0003-0379-8866)
- Hua Lin (ORCID: https://orcid.org/0000-0001-5393-0322)
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Jike Qi
- Ping Zeng (ORCID: https://orcid.org/0000-0002-2719-1009)
- Ziqi Jiang (ORCID: https://orcid.org/0000-0003-0637-4540)
- Yuchen Jiang (ORCID: https://orcid.org/0000-0001-8284-3834)
- Xinyi Wang (ORCID: https://orcid.org/0000-0003-4255-6595)
- Yuxin Liu (ORCID: https://orcid.org/0009-0005-0495-6944)
- Weiyi Song
- Hongyan Cao
- Shuo Zhang
- Ke Wang
- Ting Wang
- Yu Yan
- Chu Zheng
Institutions
- Shanxi Medical University (CN)
- Xuzhou Medical College (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Global Health
- Published
- 2026-02-13
- DOI
- https://doi.org/10.7189/jogh.16.04060
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00