Novel deuterium metabolic imaging technique reveals distinct patterns of postprandial hepatic glucose homeostasis in individuals with type 1 diabetes and healthy control individuals: a case–control study
By integrating DMI/<sup>13</sup>C-MRS liver imaging with systemic stable-isotope modelling, this comparative study demonstrates significantly altered hepatic glucose metabolism in adults with well-managed type 1 diabetes vs control individuals, together with substantial phenotypic heterogeneity within the type 1 diabetes cohort. These findings highlight the potential of non-invasive metabolic phenotyping to resolve metabolic alterations and inter-individual variation in type 1 diabetes, which are essential steps towards the provision of precision medicine.
Authors
- David Herzig (ORCID: https://orcid.org/0000-0003-1028-9445)
- L Bally
- Simone Poli (ORCID: https://orcid.org/0000-0001-5676-3187)
- Michele Schiavon (ORCID: https://orcid.org/0000-0003-0590-2399)
- Naomi F. Lange (ORCID: https://orcid.org/0000-0002-9519-4949)
- Alessandro Brunasso
- Chiara Dalla Man
- Roland Kreis
Institutions
- University of Bern (CH)
- University of Padua (IT)
- University Hospital of Bern (CH)
Publication Details
- Journal
- Diabetologia
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1007/s00125-026-06677-7
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- University of Bern
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Université de Lausanne