Hepatic Encephalopathy is the Key Driver of Symptom Burden in a Longitudinal Cohort of Patients With Advanced Chronic Liver Disease: PAL-LIVER Substudy
Symptom burden in cirrhosis is generally stable but remain high among certain subgroups, especially those with HE. HE is the strongest and most consistent determinant of physical, psychological, and caregiver burden in cirrhosis. These findings highlight the urgent need for novel, HE-targeted interventions and comprehensive symptom management strategies particularly for women and those with alcohol-related liver disease.
Authors
- Christopher D. Woodrell (ORCID: https://orcid.org/0000-0002-2728-2779)
- Manisha Verma (ORCID: https://orcid.org/0000-0003-4917-1380)
- Elliot B. Tapper (ORCID: https://orcid.org/0000-0002-0839-1515)
- Mina O. Rakoski
- A S Kosinski
- Ronald Huang
Institutions
- Duke University (US)
- Loma Linda University (US)
- University of Michigan (US)
- Thomas Jefferson University Hospital (US)
- Clinical Research Institute (US)
- James J. Peters VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.14309/ajg.0000000000003964
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00