New Nicotinonitrile–Coumarin Heterodimers: Synthesis and Evaluation of Agrochemical Potential
Previously undescribed nicotinonitrile–coumarin hybrids, namely 2-{[2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl]thio}pyridine-3-carbonitriles and -quinoline-3-carbonitriles, were synthesized via the reaction of 2-thioxo-1,2-dihydropyridine-3-carbonitriles with 3-(bromoacetyl)coumarin or 3-(bromoacetyl)benzo[f]coumarin in the presence of sodium propylate. Under laboratory conditions on sunflower seedlings, some of the prepared compounds exhibited a pronounced antidote effect against the herbicide 2,4-D, as well as moderate growth-stimulating activity.
Authors
- С. Г. Кривоколыско (ORCID: https://orcid.org/0000-0001-9879-9217)
- Nicolai A. Aksenov (ORCID: https://orcid.org/0000-0002-7125-9066)
- E. E. Netreba (ORCID: https://orcid.org/0000-0001-9292-1904)
- Victor V. Dotsenko (ORCID: https://orcid.org/0000-0001-7163-0497)
- Tagir L. Salakhov
- Elena P. Dotsenko
- Inna V. Aksenova
- Daria Yu. Lukina
- Vladimir D. Strelkov
Institutions
- Kuban State University (RU)
- Kherson National Technical University (UA)
- North-Caucasus Federal University (RU)
- Luhansk State Medical University (UA)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1134/s1070363225608488
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00