Multivariable Mendelian randomization analysis reveals the protective effect of restless legs syndrome against lower limb venous diseases and pulmonary embolism
RLS may lower the risk of venous diseases and pulmonary embolism, an effect that may be partly explained by nocturnal limb activity. This finding is particularly relevant for pregnant women and individuals with renal impairment, who are at high risk for both RLS and VTE. Further research is needed to validate these conclusions.
Authors
- Cheng Wen (ORCID: https://orcid.org/0000-0002-2538-0439)
- Fu-jia LI
- Yiqiang Zhan (ORCID: https://orcid.org/0000-0001-5815-9725)
- Zhuo-Ying Lai
- Ru-Lin Geng
- Jie-Hua Su
- Ru-Yu Zhang
- Xiao-Huan Liu
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen University Health Science Center (CN)
- Zigong First People's Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- SLEEP
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1093/sleep/zsag038
- Primary Topic
- Restless Legs Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00