Pimozide Reprograms the Ran GTPase–SCF Axis and Matrix Remodeling Pathways in Breast, Colorectal, and Pancreatic Cancer Models
Pimozide exerts anticancer effects through coordinated disruption of nucleocytoplasmic transport, proteostasis regulation, and matrix remodeling. These findings support the repositioning of pimozide as a multi-target anticancer agent and provide a mechanistic foundation for further translational investigation.
Authors
- Shakta Mani Satyam (ORCID: https://orcid.org/0000-0001-5761-2073)
- Khaled Abdul‐Aziz Ahmed (ORCID: https://orcid.org/0000-0002-2194-6669)
- A. Ibrahim (ORCID: https://orcid.org/0000-0002-3053-2177)
- Razan Madi (ORCID: https://orcid.org/0000-0002-0103-1058)
- Hayat Asaad Hameed Al-Ali
- Talal Salem Al-Qaisi
- Mohammad El-Tanani
- Rahmeh Khirfan
- Yusuf Lukman
- Razan Obiedat
Institutions
- Al-Ahliyya Amman University (JO)
- Hospital Universiti Sains Malaysia (MY)
- Federal Medical Centre (NG)
- Ras al-Khaimah Medical and Health Sciences University (AE)
Publication Details
- Journal
- Cancers
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3390/cancers18040611
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Al-Ahliyya Amman University