Leukocyte Chemotactic Factor 2 Amyloidosis ( <scp>LECT</scp> ‐2) Amyloidosis Case Report and Review of the Current Literature
Amyloid deposition is an increasingly recognized contributor to chronic kidney disease and end-stage renal disease. It can result from various underlying conditions, including monoclonal gammopathies and chronic inflammatory states. Diagnosis is typically established by kidney biopsy demonstrating characteristic amyloid deposits. ALECT2 (leukocyte chemotactic factor 2) amyloidosis can present as nephrotic-range proteinuria. ALECT2 amyloidosis is an uncommon and under-recognized.
Authors
- Catherine Abendroth (ORCID: https://orcid.org/0000-0002-1036-3652)
- Bayan Matarneh (ORCID: https://orcid.org/0000-0001-6733-6199)
- Ahmad Matarneh (ORCID: https://orcid.org/0000-0002-7091-310X)
- Navin Kumar Verma (ORCID: https://orcid.org/0000-0002-5940-6633)
- Omar Salameh (ORCID: https://orcid.org/0000-0002-9190-0439)
- Sundus Sardar
- Nasrollah Ghahramani
Institutions
- Truman Medical Center (US)
- Detroit Medical Center (US)
- Children's Hospital of Michigan (US)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/ccr3.72055
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania
- Pennsylvania State University