Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare <i>SORL1</i> variants
Enzyme-linked immunosorbent assay (ELISA) enables quantitative measurement of soluble sortilin-related receptor (sSORL1) in cerebrospinal fluid (CSF). sSORL1 levels are reduced in CSF from carriers of a pathogenic SORL1 variant. CSF-sSORL1 levels correlate with tau pathology in Alzheimer's disease. sSORL1 levels represent an in vivo biomarker of SORL1 function.
Authors
- Christian Bjerggaard Vægter (ORCID: https://orcid.org/0000-0001-6573-146X)
- Calvin Trieu (ORCID: https://orcid.org/0000-0001-6266-2198)
- Dovile Januliene (ORCID: https://orcid.org/0000-0002-3279-7590)
- Giulia Monti (ORCID: https://orcid.org/0000-0001-9404-1273)
- Dáša Bohačiaková (ORCID: https://orcid.org/0000-0002-9538-6668)
- Lynn Boonkamp (ORCID: https://orcid.org/0000-0002-2200-0832)
- Jiří Sedmík (ORCID: https://orcid.org/0000-0002-5589-1061)
- Sona Cesnarikova (ORCID: https://orcid.org/0000-0002-7644-6207)
- O. BLEGVAD ANDERSEN
- Jan Raška (ORCID: https://orcid.org/0000-0001-7957-0214)
- Melanie Lunding
- Matthijs W. J. de Waal (ORCID: https://orcid.org/0000-0001-6746-4326)
- Arne Möller
- Georgii Ozhegov
- Henne Holstege
- Marc Hulsman
- Niccoló Tesi
- Lisa Vermunt
- Sven J. van der Lee
- Anne Mette G. Jensen
- Wiesje M. van der Flier
- Nolan Barrett
- Marjan M. Weiss
- Charlotte E. Teunissen
- Rosalina van Spaendonk
Institutions
- Allen Institute for Brain Science (US)
- Radboud University Nijmegen (NL)
- Osnabrück University (DE)
- Aarhus University (DK)
- Masaryk University (CZ)
- Radboud University Medical Center (NL)
- Amsterdam Neuroscience (NL)
- International Clinical Research Center, St. Anne's University Hospital Brno (CZ)
- Alzheimer Nederland (NL)
- St. Anne's University Hospital Brno (CZ)
- Public Health Service of Amsterdam (NL)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Hochschule Osnabrück (DE)
- Vrije Universiteit Amsterdam (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71042
- Primary Topic
- Genomic variations and chromosomal abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aarhus Universitet
- EU Joint Programme – Neurodegenerative Disease Research
- European Commission
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Agentura Pro Zdravotnický Výzkum České Republiky
- Alzheimer Nederland
- Amsterdam Neuroscience
- HORIZON EUROPE Framework Programme