Role of LIGHT in the Inflammatory Mechanisms of Psoriasis via Upregulation of Proliferation and Cytokine Production of Keratinocytes
The present findings indicate that the JNK/AP-1-HVEM-LIGHT pathway played a role in the viability of human keratinocytes and the expression of IL-6, IL-8, PGI2, and PTGS2. Thus, the JNK/AP-1-HVEM-LIGHT pathway might be a potential target for the treatment of psoriasis.
Authors
- Ying Zou
- Ting Cao (ORCID: https://orcid.org/0000-0002-4060-9174)
- Cheng‐bin Ye
- Cheng‐wen Fei
- Xu‐yang Zhou
Institutions
- Shanghai Skin Disease Hospital (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/iid3.70343
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00