Case Report: Developmental-like skeletal deformities and transient osteosclerosis as rare presentations of primary hyperparathyroidism
This case highlights two key points: first, PHPT can masquerade as developmental skeletal deformity in adolescents, mandating a high index of suspicion and biochemical screening. Second, we describe a novel, self-resolving phenomenon of transient postoperative osteosclerosis, likely representing a reparative bone response following biochemical cure. Successful orthopedic correction before full metabolic normalization underscores the feasibility of staged management with meticulous perioperative care. These observations expand the phenotypic spectrum of pediatric PHPT.
Authors
- Jingyi Huang (ORCID: https://orcid.org/0000-0002-1209-9699)
- Yunfa. Yang
- Haiying Wu (ORCID: https://orcid.org/0000-0002-8943-5267)
- Xu Gao (ORCID: https://orcid.org/0000-0001-9040-4970)
- Peijun Deng
- Junbo Liang
- Miaoxian Huang
- Qin Wang
- Jie Li
- Mi Zhou
Institutions
- Mianyang Third People's Hospital (CN)
- Tongde Hospital of Zhejiang Province (CN)
- Guangzhou First People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fendo.2026.1672914
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Municipal Science and Technology Project