Case Report: Developmental-like skeletal deformities and transient osteosclerosis as rare presentations of primary hyperparathyroidism

This case highlights two key points: first, PHPT can masquerade as developmental skeletal deformity in adolescents, mandating a high index of suspicion and biochemical screening. Second, we describe a novel, self-resolving phenomenon of transient postoperative osteosclerosis, likely representing a reparative bone response following biochemical cure. Successful orthopedic correction before full metabolic normalization underscores the feasibility of staged management with meticulous perioperative care. These observations expand the phenotypic spectrum of pediatric PHPT.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-02-13
DOI
https://doi.org/10.3389/fendo.2026.1672914
Primary Topic
Parathyroid Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Case Report: Developmental-like skeletal deformities and transient osteosclerosis as rare presentations of primary hyperparathyroidism

Jingyi Huang, Yunfa. Yang, Haiying Wu, Xu Gao et al.
Frontiers in Endocrinology
Parathyroid Disorders and Treatments
article

Case Report: Developmental-like skeletal deformities and transient osteosclerosis as rare presentations of primary hyperparathyroidism

Jingyi Huang, Yunfa. Yang, Haiying Wu, Xu Gao, Peijun Deng, Junbo Liang, Miaoxian Huang, Qin Wang, Jie Li, Mi Zhou
article en

Abstract

This case highlights two key points: first, PHPT can masquerade as developmental skeletal deformity in adolescents, mandating a high index of suspicion and biochemical screening. Second, we describe a novel, self-resolving phenomenon of transient postoperative osteosclerosis, likely representing a reparative bone response following biochemical cure. Successful orthopedic correction before full metabolic normalization underscores the feasibility of staged management with meticulous perioperative care. These observations expand the phenotypic spectrum of pediatric PHPT.

Frontiers in EndocrinologyVol. 17
Mianyang Third People's Hospital (CN), Tongde Hospital of Zhejiang Province (CN), Guangzhou First People's Hospital (CN), Guangzhou Medical University (CN)
Guangzhou Municipal Science and Technology Project
Openalex Percentile: Top 61%
Parathyroid Disorders and Treatments
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Case Report: Developmental-like skeletal deformities and transient osteosclerosis as rare presentations of primary hyperparathyroidism — Jingyi Huang, Yunfa. Yang, et al. · Frontiers in Endocrinology (2026) | TGRS Research Map | TGRS