A rare ORAI1 missense variant associates with risk of vascular diseases in White British adults
Our results reveal an association between an ORAI1 missense variant and hospitalisation for peripheral vascular disease, generalised atherosclerosis, acute ischaemic heart disease, and atrioventricular and left bundle-branch block. These findings provide a novel insight into the role of ORAI1 in vascular remodelling and highlight its potential as a treatment target for vascular pathologies.
Authors
- Karen E. Hemmings (ORCID: https://orcid.org/0000-0002-4967-6314)
- David J. Beech (ORCID: https://orcid.org/0000-0002-7683-9422)
- Heba Shawer (ORCID: https://orcid.org/0000-0003-1813-427X)
- Chew W. Cheng
- Fabio Stocco (ORCID: https://orcid.org/0000-0001-5102-1045)
- Jian Shi
- Gonzalo Revilla-González
- Marc A. Bailey
- Abeer M. Aldawsari
Institutions
- Leeds General Infirmary (GB)
- University of Leeds (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- King Saud University (SA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1371/journal.pone.0337519
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00