CCR8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction–Induced Tissue Damage
Our findings reveal a 2-phase Treg specialization process and establish the CCL1-CCR8 axis as a crucial pathway for Treg recruitment and function in the infarcted heart. Therapeutic targeting of this axis may improve immune-regulated cardiac repair after MI.
Authors
- Zhiheng Hao (ORCID: https://orcid.org/0009-0008-2705-1015)
- JingYong Li
- Jun He (ORCID: https://orcid.org/0000-0002-1479-285X)
- Z. Jeffrey Chen
- N Li (ORCID: https://orcid.org/0000-0001-9933-8674)
- Yuzhi Lu (ORCID: https://orcid.org/0000-0002-2253-7111)
- Muyang Gu
- Rui Gao (ORCID: https://orcid.org/0000-0001-5170-6861)
- Yang Fen (ORCID: https://orcid.org/0000-0003-0174-2949)
- Ni Xia
- Jiao Jiao (ORCID: https://orcid.org/0000-0002-9413-9964)
- Jie Cai (ORCID: https://orcid.org/0000-0002-6126-5083)
- Weimin Wang (ORCID: https://orcid.org/0000-0001-7617-8284)
- Meilin Liu
- Zhilei Shan
- Xiang Cheng
- Qing Wang
- Min Zhang
- Chen Chen
- Yuhan Shen
- Desheng Hu
- Haoyi Yang
Institutions
- Union Hospital (HK)
- Hubei University of Chinese Medicine (CN)
- Mahindra and Mahindra Limited (India) (IN)
- Wuhan Union Hospital (CN)
- Huazhong University of Science and Technology Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University of Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1161/circulationaha.125.076426
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00