Case Report: Tezepelumab as rescue therapy in near-fatal asthma requiring extracorporeal membrane oxygenation
In this small series, adjunctive tezepelumab during VV-ECMO-supported status asthmaticus appeared safe and potentially beneficial adjunctive therapy during near-fatal asthma requiring VV-ECMO. Randomized controlled studies are needed to determine the impact of TSLP inhibition on recovery time, ventilation duration, and mortality in this setting.
Authors
- István Vadász (ORCID: https://orcid.org/0000-0003-1370-9783)
- Khodr Tello (ORCID: https://orcid.org/0000-0002-5557-623X)
- Gani Oruqaj
- J Bewersdorff
- Werner Seeger
- Detlef Litzlbauer
- Matthias Hecker
- Friedrich Grimminger
- Matthias Wolff
- Michael Sander
Institutions
- Justus-Liebig-Universität Gießen (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- Lung Institute (US)
- Universities of Giessen and Marburg Lung Center (DE)
- Nini Hospital (LB)
- Cardio-Pulmonary Institute (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fimmu.2026.1722963
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00