Recent advance on diagnosis and treatment of solid pseudopapillary neoplasm of the pancreas
Solid pseudopapillary neoplasm (SPN) of the Pancreas is a low-grade malignant pancreatic tumor characterized by low incidence and a predilection for young female patients. It exhibits unique histological and biological features, and its diagnosis and management differ significantly from those of more common pancreatic ductal adenocarcinoma and pancreatic cystic neoplasms, or the less common pancreatic neuroendocrine neoplasms. Surgical resection yields favorable outcomes for SPN; however, a minority of patients experience recurrence and metastasis. High-risk factors for recurrence and metastasis are increasingly being identified. To incorporate recent advances in the diagnosis and management of SPN and to advance the field, this review summarizes the highest level of evidence within the discipline, incorporating clinical expert experience. The goal is to summarize diagnostic and therapeutic strategies for SPN, thereby enhancing overall clinical outcomes.
Authors
- G. Wang
- Guangbing Li
- Bo Kong (ORCID: https://orcid.org/0000-0002-8200-7817)
- Zhiwen xiao
- Feng Yang (ORCID: https://orcid.org/0000-0001-5164-5413)
- Carl-Stephan Leonhardt (ORCID: https://orcid.org/0009-0001-7179-9580)
- Philip C. Müller (ORCID: https://orcid.org/0000-0001-8317-3449)
- Y Hanna Wen (ORCID: https://orcid.org/0009-0005-5160-4597)
- Sheng Jiyao
- Luo G
- Qiaofei Liu
- Xiangsong Wu
- HanXiang Zhan
- F. Nickel
- Daisuke Hashimoto
- Shiwei Guo
- B Zhou
- Giovanni Marchegiani
- Tao Ma
- Wei Cheng
- Yong An
- Dong Wang
Institutions
- Qingdao University (CN)
- Kansai Medical University (JP)
- Naval Medical Research Command (US)
- University of Padua (IT)
- Central South University (CN)
- Harbin Medical University (CN)
- Universität Hamburg (DE)
- Heidelberg University (DE)
- Sichuan University (CN)
- Peking Union Medical College Hospital (CN)
- XinHua Hospital (CN)
- University Hospital of Basel (CH)
- West China Hospital of Sichuan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- The First People's Hospital of Changzhou (CN)
- University Medical Center Hamburg-Eppendorf (DE)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Hunan Provincial People's Hospital (CN)
- Beijing Friendship Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Huashan Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Medical University of Vienna (AT)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Pancreatology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1097/jp9.0000000000000257
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00