Development and external validation of a mitophagy-related diagnostic model for biliary atresia based on cellular infiltration patterns

This study establishes the BA-CIMDGM model as a valuable diagnostic tool for BA and proposes Cyclosporine as a potential pharmacological intervention. These findings underscore the clinical relevance of mitophagy-related genes and offer novel insights for improving both diagnosis and therapy in BA.

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Publication Details

Journal
Translational Pediatrics
Published
2026-02-01
DOI
https://doi.org/10.21037/tp-2025-1-864
Primary Topic
Pediatric Hepatobiliary Diseases and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Development and external validation of a mitophagy-related diagnostic model for biliary atresia based on cellular infiltration patterns

Shixuan Zhang, Dayan Sun, Junmin Liao, Jingbin Du et al.
Translational Pediatrics
Pediatric Hepatobiliary Diseases and Treatments
article

Development and external validation of a mitophagy-related diagnostic model for biliary atresia based on cellular infiltration patterns

Shixuan Zhang, Dayan Sun, Junmin Liao, Jingbin Du, Jianguo Zhang, Yanan Zhang, Yichao Gu, Dingding Wang, Kaiyun Hua, Jinshi Huang, Yong Zhao
article en

Abstract

This study establishes the BA-CIMDGM model as a valuable diagnostic tool for BA and proposes Cyclosporine as a potential pharmacological intervention. These findings underscore the clinical relevance of mitophagy-related genes and offer novel insights for improving both diagnosis and therapy in BA.

Translational PediatricsVol. 15(2)
Pudong Medical Center (CN), Beijing Children’s Hospital (CN), Jiangxi Provincial Children's Hospital (CN), Inner Mongolia Maternal and Child Health (CN)
Good health and well-being
Openalex Percentile: Top 56%
Pediatric Hepatobiliary Diseases and Treatments
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