Lycopene Enhances the Sensitivity of Oral Squamous Cell Carcinoma to Cisplatin Through Inhibition of the PI3K/Akt Signaling Pathway and Reversal of Epithelial-Mesenchymal Transition
This is the first report that lycopene enhances cisplatin sensitivity in OSCC by coupling inhibition of MRP-1-mediated drug efflux with suppression of PI3K/Akt/mTOR and EMT/stemness-filling the gap of lycopene's synergistic mechanism with cisplatin, offering a strategy to improve therapeutic efficacy without exacerbating toxicity.
Authors
- Zhaochen Shan
- R Yu
- Xinxing Lu
- Ran Wang
Institutions
- Capital Medical University (CN)
- Ministry of Education (ET)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/dddt.s557101
- Primary Topic
- Antioxidant Activity and Oxidative Stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00