Association Between Serum Vitamin D Levels and Metformin Efficacy in Obese Type 2 Diabetes Patients: A Retrospective Cohort Study Based on HbA1c Reduction

Higher baseline vitamin D levels (≥20 ng/mL) are associated with significantly improved metformin efficacy in obese T2DM patients, particularly among females, older adults, and those with poorer glycemic control. Vitamin D status may serve as a predictive biomarker for metformin response.

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Publication Details

Journal
Therapeutics and Clinical Risk Management
Published
2026-02-01
DOI
https://doi.org/10.2147/tcrm.s565034
Primary Topic
Vitamin D Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Association Between Serum Vitamin D Levels and Metformin Efficacy in Obese Type 2 Diabetes Patients: A Retrospective Cohort Study Based on HbA1c Reduction

Hongli Liu, Yijia Li, Chen He, Zhi Wei et al.
Therapeutics and Clinical Risk Management
Vitamin D Research Studies
article

Association Between Serum Vitamin D Levels and Metformin Efficacy in Obese Type 2 Diabetes Patients: A Retrospective Cohort Study Based on HbA1c Reduction

Hongli Liu, Yijia Li, Chen He, Zhi Wei, Xiaoxue Wang
article en

Abstract

Higher baseline vitamin D levels (≥20 ng/mL) are associated with significantly improved metformin efficacy in obese T2DM patients, particularly among females, older adults, and those with poorer glycemic control. Vitamin D status may serve as a predictive biomarker for metformin response.

Therapeutics and Clinical Risk ManagementVol. Volume 22
Hanzhong Central Hospital (CN)
No poverty
Openalex Percentile: Top 58%
Vitamin D Research Studies
DOIOpen Access PDFOpenAlex
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Association Between Serum Vitamin D Levels and Metformin Efficacy in Obese Type 2 Diabetes Patients: A Retrospective Cohort Study Based on HbA1c Reduction — Hongli Liu, Yijia Li, et al. · Therapeutics and Clinical Risk Management (2026) | TGRS Research Map | TGRS