Low-density lipoprotein cholesterol lowering and risk of major adverse cardiovascular events in primary prevention trials: A meta-analysis
In CVOTs of solely or predominantly primary prevention participants, each 1 mmol/L reduction in LDL-C was associated with a 30% RRR in 4-point MACE. These results strengthen the evidence and rationale for the benefits of LDL-C lowering in primary prevention.
Authors
- Pamela Kushner (ORCID: https://orcid.org/0000-0002-5871-1265)
- Meredith L. Wilcox (ORCID: https://orcid.org/0000-0001-6696-4935)
- Carol F Kirkpatrick
- Dinesh Kalra
- Archna Bajaj
- Kevin C. Maki
- Kausik K. Ray
- Mary R. Dicklin
Institutions
- Idaho State University (US)
- University of Louisville (US)
- Xilinx (United States) (US)
- University of California, Irvine Medical Center (US)
- Indiana University Bloomington (US)
- Babcock & Wilcox (United States) (US)
- Imperial College London (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of clinical lipidology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jacl.2026.02.006
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 39.15
Funders
- Esperion Therapeutics