FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

FASN drives CD4<sup>+</sup> T cell hyperactivation and metabolic reprogramming in SS. Its inhibition shifts cell metabolism from glycolysis to OXPHOS, reducing inflammation and ameliorating disease in preclinical models. These results identify FASN as a potential therapeutic target for SS.

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Publication Details

Journal
Arthritis Research & Therapy
Published
2026-02-13
DOI
https://doi.org/10.1186/s13075-026-03765-2
Primary Topic
Salivary Gland Disorders and Functions
Type
article
Field-Weighted Citation Impact
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article

FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

BaoLi Wang, Xijun Wang, jiayao fu, Lingyan Zheng et al.
Arthritis Research & Therapy
Salivary Gland Disorders and Functions
article

FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation

BaoLi Wang, Xijun Wang, jiayao fu, Lingyan Zheng, Lei Ye, Huan Shi, Junhao Yin
article en

Abstract

FASN drives CD4<sup>+</sup> T cell hyperactivation and metabolic reprogramming in SS. Its inhibition shifts cell metabolism from glycolysis to OXPHOS, reducing inflammation and ameliorating disease in preclinical models. These results identify FASN as a potential therapeutic target for SS.

Arthritis Research & TherapyVol. 28(1)
Tongji University (CN), Second Military Medical University (CN), Shanghai Jiao Tong University (CN), National Clinical Research Center for Digestive Diseases (CN), Shanghai Stomatological Hospital (CN), Shanghai Ninth People's Hospital (CN), National Clinical Research (US), Shanghai Clinical Research Center (CN)
Good health and well-being
Openalex Percentile: Top 54%
Salivary Gland Disorders and Functions
DOIOpen Access PDFOpenAlex
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FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation — BaoLi Wang, Xijun Wang, et al. · Arthritis Research & Therapy (2026) | TGRS Research Map | TGRS