Human umbilical mesenchymal stem cell-derived mitochondria transplantation suppresses sFLT-1 secretion by regulating calcineurin-NFAT-dependent pathways in angiotensin II-induced preeclampsia rats
This study demonstrates that Mito-T reverses the pathological phenotypes of PE rats by improving placental mitochondrial activity and suppressing trophoblast-derived sFLT-1 production. These findings provide proof-of-concept evidence that Mito-T could serve as a potential therapeutic strategy for reducing maternal and foetal risks in patients with PE.
Authors
- Jun Xian Liu
- Young Cheol Kang
- Hui Xing Cui
- Kyuboem Han
- Chun-Hyung Kim
- Hong Kyu Lee
- Yin Hua Zhang
Institutions
- Seoul National University (KR)
- Yanbian University (CN)
- Association of Southeast Asian Nations (ID)
- National University College (PR)
- Yanbian University Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Samil Pharm (South Korea) (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1186/s13287-026-04930-9
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Natural Science Foundation of China
- Seoul National University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- College of Medicine, Seoul National University