Postnatal Azithromycin Is Neuroprotective and Anti-Inflammatory in a Piglet Model of Hypoxic-Ischemic Encephalopathy
Azithromycin, administered after inflammation-amplified hypoxia-ischemia was safe and associated with increased neuronal survival, microglial immunomodulation, enhanced amplitude-integrated encephalography recovery, and a modest benefit on lactate to N-acetyl aspartate peak area ratio. These safety and efficacy data of azithromycin as a monotherapy hold promise to improve outcomes for hypoxic-ischemic encephalopathy in low- and middle-income countries.
Authors
- Christopher Meehan
- M. Hristova
- George Maple
- Alison Mintoft
- Yujin Kim (ORCID: https://orcid.org/0000-0002-7186-221X)
- N. A. E. Robertson
- Francisco Torrealdea
- Ivana d’Angelo (ORCID: https://orcid.org/0000-0003-0444-0444)
- Raymand Pang
- Manjunath P. Pai
- John Barks
Institutions
- University College Hospital (GB)
- University of Michigan (US)
- Michigan Medicine (US)
- UCL Biomedical Research Centre (GB)
- Institute for Reproductive Health (US)
- University College London (GB)
Publication Details
- Journal
- Stroke
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1161/strokeaha.125.054318
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00