Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With <scp>MS</scp>
Despite similar brain volumes and lesion load, B-PwMS showed a greater rearrangement of brain structural and functional connectivity within the SMN and DMN when compared with NHW-PwMS. Moreover, B-PwMS showed a higher degree of structure-function decoupling in the SMN, with a trend towards association with increased physical disability.
Authors
- Jonathan Howard (ORCID: https://orcid.org/0000-0003-2658-3219)
- Pietro Bontempi (ORCID: https://orcid.org/0000-0002-7720-8243)
- Fred A. Lublin
- Emilio Cipriano (ORCID: https://orcid.org/0000-0003-0304-0529)
- Sylvia Klineova (ORCID: https://orcid.org/0000-0002-0406-0460)
- Nicole Graziano
- Maria Petracca
- Claire Wigley (ORCID: https://orcid.org/0009-0000-1825-8155)
- Claire S Riley
- Marta Ponzano
- Giacomo Boffa
Institutions
- University of Verona (IT)
- Columbia University Irving Medical Center (US)
- Ospedale Policlinico San Martino (IT)
- New York University (US)
- University of Genoa (IT)
- Sapienza University of Rome (IT)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1002/acn3.70331
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health