Lactylation-drived TRIM29 induces invasive behavior and lymph node metastasis in gastric cancer via hnRNPA1-mediated Wnt/β-catenin pathway

Lactylation of TRIM29 promotes invasive behavior and lymph node metastasis in GC cells by engaging the hnRNPA1-mediated Wnt/β-catenin pathway. Targeting TRIM29 and lymphangiogenesis may be a promising therapeutic strategy for patients with advanced GC.

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Publication Details

Journal
Cell Death and Disease
Published
2026-02-13
DOI
https://doi.org/10.1038/s41419-026-08468-9
Primary Topic
interferon and immune responses
Type
article
Field-Weighted Citation Impact
0.00

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article

Lactylation-drived TRIM29 induces invasive behavior and lymph node metastasis in gastric cancer via hnRNPA1-mediated Wnt/β-catenin pathway

Qingfeng Ni, Yuanjie Niu, Ruheng Hua, Boyang Hu et al.
Cell Death and Disease
interferon and immune responses
article

Lactylation-drived TRIM29 induces invasive behavior and lymph node metastasis in gastric cancer via hnRNPA1-mediated Wnt/β-catenin pathway

Qingfeng Ni, Yuanjie Niu, Ruheng Hua, Boyang Hu, Jiawei Yu, Yang Wang, Zhenwei Han, Jianwei Zhu
article en

Abstract

Lactylation of TRIM29 promotes invasive behavior and lymph node metastasis in GC cells by engaging the hnRNPA1-mediated Wnt/β-catenin pathway. Targeting TRIM29 and lymphangiogenesis may be a promising therapeutic strategy for patients with advanced GC.

Cell Death and DiseaseVol. 17(1)
Nantong University (CN), Affiliated Hospital of Nantong University (CN)
Jiangsu Commission of Health, Nantong University, Nantong Science and Technology Bureau
Good health and well-being
Openalex Percentile: Top 55%
interferon and immune responses
DOIOpen Access PDFOpenAlex
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Lactylation-drived TRIM29 induces invasive behavior and lymph node metastasis in gastric cancer via hnRNPA1-mediated Wnt/β-catenin pathway — Qingfeng Ni, Yuanjie Niu, et al. · Cell Death and Disease (2026) | TGRS Research Map | TGRS