Early eculizumab treatment improves renal outcomes in pediatric lupus nephritis with thrombotic microangiopathy

In pediatric LN with TMA, eculizumab outperforms conventional therapy by accelerating renal recovery. Early use-after excluding TTP, infections, and drug-related causes-may mitigate renal damage and improve outcomes. Given that this is a retrospective study with a small sample size, the findings require validation from larger-scale clinical studies.

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Publication Details

Journal
Nephrology Dialysis Transplantation
Published
2026-02-12
DOI
https://doi.org/10.1093/ndt/gfag031
Primary Topic
Complement system in diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Early eculizumab treatment improves renal outcomes in pediatric lupus nephritis with thrombotic microangiopathy

Weijie Kang, Shihan Yu, Youying Mao, Jia He et al.
Nephrology Dialysis Transplantation
Complement system in diseases
article

Early eculizumab treatment improves renal outcomes in pediatric lupus nephritis with thrombotic microangiopathy

Weijie Kang, Shihan Yu, Youying Mao, Jia He, Zhengyu Zhou, Wei Zhou, Lei Yin, Jiayao Shen, Chenxing Zhang, Jie Zhang
article en

Abstract

In pediatric LN with TMA, eculizumab outperforms conventional therapy by accelerating renal recovery. Early use-after excluding TTP, infections, and drug-related causes-may mitigate renal damage and improve outcomes. Given that this is a retrospective study with a small sample size, the findings require validation from larger-scale clinical studies.

Nephrology Dialysis Transplantation
Shanghai Medical College of Fudan University (CN), Shanghai Children's Medical Center (CN), Tongren Hospital (CN), Songjiang District Central Hospital (CN)
Good health and well-being
Openalex Percentile: Top 55%
Complement system in diseases
DOISourceOpenAlex
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Early eculizumab treatment improves renal outcomes in pediatric lupus nephritis with thrombotic microangiopathy — Weijie Kang, Shihan Yu, et al. · Nephrology Dialysis Transplantation (2026) | TGRS Research Map | TGRS