A network meta-analysis of safety and efficacy of sodium-glucose cotransporter 2 inhibitors in heart failure patients

Empagliflozin was associated with the lowest risk of both cardiovascular mortality and serious side effects. While all SGLT2 inhibitors reduced the likelihood of hospitalizations for HF, canagliflozin did not show a significant benefit in this area. There were no significant differences between the SGLT2 inhibitors in terms of all-cause mortality, MI, stroke, or side effects leading to treatment discontinuation.

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Publication Details

Journal
Annals of Medicine and Surgery
Published
2026-02-12
DOI
https://doi.org/10.1097/ms9.0000000000004669
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

A network meta-analysis of safety and efficacy of sodium-glucose cotransporter 2 inhibitors in heart failure patients

M. A. Ibraheim, Shadi Abuhashem, Zinab Alatawi, Leo Tom et al.
Annals of Medicine and Surgery
Diabetes Treatment and Management
article

A network meta-analysis of safety and efficacy of sodium-glucose cotransporter 2 inhibitors in heart failure patients

M. A. Ibraheim, Shadi Abuhashem, Zinab Alatawi, Leo Tom, Mohammed Aramin, Ashraf Mohammed Alhazmi, Ashanti Hameed, Kosar Doraghi, Mohamed Amer Alshahrani
article en

Abstract

Empagliflozin was associated with the lowest risk of both cardiovascular mortality and serious side effects. While all SGLT2 inhibitors reduced the likelihood of hospitalizations for HF, canagliflozin did not show a significant benefit in this area. There were no significant differences between the SGLT2 inhibitors in terms of all-cause mortality, MI, stroke, or side effects leading to treatment discontinuation.

Annals of Medicine and SurgeryVol. 88(3)
Nitte University (IN), University of Khartoum (SD), Al-Quds University (PS), King Fahd Medical City (SA), Centinela Hospital Medical Center (US), University of Belize (BZ), Armed Forces Hospital (SA), North West Armed Forces Hospital (SA), University of Tabuk (SA)
Good health and well-being
Openalex Percentile: Top 58%
Diabetes Treatment and Management
DOIOpen Access PDFOpenAlex
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