Highly suspected fulminant myocarditis induced by the immune checkpoint inhibitor tislelizumab: a case report with third-degree atrioventricular block and recurrent ventricular tachycardia

ICI-associated myocarditis is characterized by a low incidence but carries a high risk of fatal outcomes. Early recognition of severe cases and timely intervention can substantially improve prognosis. In this case, fulminant myocarditis related to the ICI tislelizumab was highly suspected but not pathologically confirmed, as cardiac magnetic resonance imaging and endomyocardial biopsy were not performed. Despite this limitation, the case may still provide a useful clinical reference for the diagnosis and management of severe ICI-associated myocarditis.

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Publication Details

Journal
Frontiers in Cardiovascular Medicine
Published
2026-02-13
DOI
https://doi.org/10.3389/fcvm.2026.1726826
Citations
1
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
24.20

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article

Highly suspected fulminant myocarditis induced by the immune checkpoint inhibitor tislelizumab: a case report with third-degree atrioventricular block and recurrent ventricular tachycardia

Wenwen Zhang, YUQUAN HE, Beibei Du, Neil Johnson et al.
1 citations
Frontiers in Cardiovascular Medicine
Cancer Immunotherapy and Biomarkers
24.20
article

Highly suspected fulminant myocarditis induced by the immune checkpoint inhibitor tislelizumab: a case report with third-degree atrioventricular block and recurrent ventricular tachycardia

Wenwen Zhang, YUQUAN HE, Beibei Du, Neil Johnson, Yingyi Su, Miao Liu, Zhiqiang Wang, Junru Qu
article en
1 citations

Abstract

ICI-associated myocarditis is characterized by a low incidence but carries a high risk of fatal outcomes. Early recognition of severe cases and timely intervention can substantially improve prognosis. In this case, fulminant myocarditis related to the ICI tislelizumab was highly suspected but not pathologically confirmed, as cardiac magnetic resonance imaging and endomyocardial biopsy were not performed. Despite this limitation, the case may still provide a useful clinical reference for the diagnosis and management of severe ICI-associated myocarditis.

Frontiers in Cardiovascular MedicineVol. 13
Union Hospital (HK), Jilin University (CN), Changchun University of Chinese Medicine (CN)
National Natural Science Foundation of China, Department of Finance of Jilin Province
Good health and well-being
Openalex Percentile: Top 1%
Cancer Immunotherapy and Biomarkers
24.20
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Highly suspected fulminant myocarditis induced by the immune checkpoint inhibitor tislelizumab: a case report with third-degree atrioventricular block and recurrent ventricular tachycardia — Wenwen Zhang, YUQUAN HE, et al. · Frontiers in Cardiovascular Medicine (2026) | TGRS Research Map | TGRS