Cross-organ communication based on non-coding RNA networks leads to cognitive dysfunction in mice

Our results suggest the involvement of multiple cross-organ regulatory mechanisms for single gene-associated intellectual disability. For FTSJ1 deficiency, this indicates that the cognitive impairment presented by affected human individuals can be associated with metabolic impairment and ceRNA crosstalk along the liver-brain and kidney-brain axes. Our findings provide a new perspective on the development of cognitive impairments caused by mutations of individual genes and underline the importance of multi-omics cross-organ analyses for the development of therapeutics and identification of biomarkers based on ceRNA-mediated networks.