Association of Systemic Inflammatory Markers With Cerebral Small Vessel Disease Progression
This community-based prospective study demonstrated that elevated NLR, MLR, and SII were associated with progression of total CSVD burden and progression of white matter hyperintensity, incident lacunes, and CMBs over ∼4.7 years, supporting their potential to provide additional context for CSVD preventive considerations. Limitations include study's single-city population and the lack of dynamic changes in inflammatory markers.
Authors
- Dingwen Zhang (ORCID: https://orcid.org/0000-0001-8369-8886)
- Y. C. Yang
- Yongjun Wang
- Jingping Sun
- Guanyu Niu
- Ziqian Xu
- Xueli Cai
- Ziyan Zhang
- Yilong Wang
- Jing Jing
- Yuesong Pan
Institutions
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Lishui Central Hospital (CN)
- Lishui City People's Hospital (CN)
Publication Details
- Journal
- Neurology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1212/wnl.0000000000214711
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00