A retrospective pilot crossover study of protocolized transition from inhaled nitric oxide to inhaled epoprostenol in adult cardiothoracic surgery
In this pragmatic, retrospective pilot study, protocolized transition from iNO to iEPO was safe, feasible, and well tolerated in a diverse cardiothoracic surgical population. The findings support iEPO as a cost-conscious alternative to iNO in the postoperative setting, with preserved hemodynamic stability and minimal changes in oxygenation. These results contribute to the growing evidence base for implementing standardized iPVD protocols in real-world practice.
Authors
- Mathew Bean
- Mary Cooter-Wright
- Joachim Meyer (ORCID: https://orcid.org/0000-0002-1801-9987)
- Kamrouz Ghadimi (ORCID: https://orcid.org/0000-0002-9287-7541)
- Tania D’Amico (ORCID: https://orcid.org/0000-0001-5303-0164)
- J. Cappiello
- C. Milano
- Yaron D. Barac
- Shanee Dim
Institutions
- Boise State University (US)
- University of Colorado Hospital (US)
- Tel Aviv University (IL)
- Duke University (US)
- Duke Medical Center (US)
- Wake Forest University (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- JHLT Open
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1016/j.jhlto.2026.100516
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00