The contribution of ferroptosis to the epithelial-mesenchymal transition phenotype in models of age-related macular degeneration
Our findings suggest that ferroptosis may contribute to linking RPE senescence with EMT, potentially via oxidative stress pathways. The combined targeting of both senescence and ferroptosis could therefore represent a potential therapeutic strategy for addressing RPE dysfunction and AMD progression.
Authors
- Xingyu Yang (ORCID: https://orcid.org/0000-0001-6145-4522)
- Hang Xie (ORCID: https://orcid.org/0009-0004-5189-4320)
- Xiaoyu Guo
- Feiyan Zhu
- Weichen Xu
- Yiqiao Xing
Institutions
- Wuhan University (CN)
- Eye Center (SA)
- Renmin Hospital of Wuhan University (CN)
- Smith-Kettlewell Eye Research Institute (US)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fcell.2026.1718715
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China