PDGFD maintains ovine tail ADSCs in a proliferative state by suppressing CXCL8 and activating PI3K/MAPK signaling
We conclude that <i>PDGFD</i> is a master regulator of adipose tissue plasticity, driving progenitor expansion via a CXCL8-dependent mechanism. This PDGFD-CXCL8 regulatory axis orchestrates the cellular groundwork essential for the extensive fat deposition that defines the ovine fat-tail phenotype.
Authors
- Beibit Turganbekovich Kulatayev (ORCID: https://orcid.org/0000-0003-1567-4713)
- Qianqian Liang (ORCID: https://orcid.org/0000-0001-8976-1612)
- George Zhang (ORCID: https://orcid.org/0000-0003-2073-7109)
- Mahaba Rouzi
- Jilong Han
- Xianshu Wang
- Pengchen Wan
- Min Yang
Institutions
- Shihezi University (CN)
- Xinjiang Academy of Agricultural and Reclamation Science (CN)
- Kazakh National Agrarian Research University (KZ)
- Xinjiang Uygur Autonomous Region Education Department (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fvets.2026.1777426
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00