The temporal sequence of myasthenia gravis and neuromyelitis optica spectrum disorder: a case report and systematic review of 74 patients
This study suggests a consistent temporal pattern wherein MG predominantly precedes NMOSD, often by years, suggesting a possible shared autoimmune predisposition. The observed response to eculizumab highlights complement pathway inhibition as a potentially effective therapeutic strategy for this complex overlap syndrome, warranting further investigation.
Authors
- Jingru Ren (ORCID: https://orcid.org/0000-0002-9186-6621)
- Hongjun Hao
- S Y Chen
- Zhenyu Niu (ORCID: https://orcid.org/0000-0003-4935-3475)
- Nan Zhang (ORCID: https://orcid.org/0000-0002-9675-5322)
- Yi Bao (ORCID: https://orcid.org/0000-0002-7563-5444)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Feng Gao
- Jing Guo
- Lanqiu Yao
- Ran Liu
Institutions
- Hubei University of Medicine (CN)
- Peking University (CN)
- Taihe Hospital (CN)
- Peking University First Hospital (CN)
- New York University (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fneur.2026.1747855
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University First Hospital
- Peking University