LINC00312 affects the progression of osteoarthritis by targeting miR-331-3p/DUSP5 axis

LINC00312 alleviates IL-1β-induced chondrocyte inflammation and apoptosis by acting as a ceRNA to regulate the miR-331-3p/DUSP5 axis. This suggests that LINC00312 may serve as a novel therapeutic target for OA.

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Publication Details

Journal
Journal of Orthopaedic Surgery and Research
Published
2026-02-13
DOI
https://doi.org/10.1186/s13018-026-06737-z
Primary Topic
Osteoarthritis Treatment and Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

LINC00312 affects the progression of osteoarthritis by targeting miR-331-3p/DUSP5 axis

Yuxiang He, Cheng Wang, Dengke Zhao, Yiming Zhao
Journal of Orthopaedic Surgery and Research
Osteoarthritis Treatment and Mechanisms
article

LINC00312 affects the progression of osteoarthritis by targeting miR-331-3p/DUSP5 axis

Yuxiang He, Cheng Wang, Dengke Zhao, Yiming Zhao
article en

Abstract

LINC00312 alleviates IL-1β-induced chondrocyte inflammation and apoptosis by acting as a ceRNA to regulate the miR-331-3p/DUSP5 axis. This suggests that LINC00312 may serve as a novel therapeutic target for OA.

Journal of Orthopaedic Surgery and ResearchVol. 21(1)
Qilu Hospital of Shandong University (CN)
Good health and well-being
Openalex Percentile: Top 58%
Osteoarthritis Treatment and Mechanisms
DOIOpen Access PDFOpenAlex
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LINC00312 affects the progression of osteoarthritis by targeting miR-331-3p/DUSP5 axis — Yuxiang He, Cheng Wang, et al. · Journal of Orthopaedic Surgery and Research (2026) | TGRS Research Map | TGRS