A data-efficient 3D medical vision-language model using only a 2D encoder

The demonstrated success of Vision-Language Models in 2D medical image analysis has motivated the extension of their capabilities to 3D volumetric data for tasks such as report generation and visual question answering. A primary obstacle to this advancement is the reliance of current approaches on specialized 3D vision encoders, whose performance is constrained by the scarcity of large-scale annotated datasets. This paper presents a data-efficient framework that bypasses the need for a 3D encoder, instead leveraging a pre-trained 2D vision encoder to process volumetric data. Our pipeline sequentially refines the visual representation. First, a cosine similarity strategy prunes redundant 2D slices to improve computational efficiency. Next, a spatial-frequency fusion module integrates spatial and frequency-domain information to model inter-slice correlations from the 2D features. Finally, a fine-grained feature injection mechanism mitigates information loss during feature compression by re-introducing high-resolution details into the final visual tokens for the Large Language Model. Evaluated on public 3D benchmarks, our framework demonstrates superior performance, achieving a METEOR score of 50.13 on M3D-Cap report generation and 82.90% accuracy on M3D-VQA, significantly outperforming previous models. Our work demonstrates a scalable and efficient paradigm for 3D medical vision-language tasks that avoids the need for 3D-specific pre-training, offering a data-efficient alternative to data-intensive 3D encoders.

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Publication Details

Journal
Scientific Reports
Published
2026-02-13
DOI
https://doi.org/10.1038/s41598-026-39526-z
Primary Topic
Multimodal Machine Learning Applications
Type
article
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article

A data-efficient 3D medical vision-language model using only a 2D encoder

Yanchun Xie, Yi Lian, Yang Jiang, Hailong Yu et al.
Scientific Reports
Multimodal Machine Learning Applications
article

A data-efficient 3D medical vision-language model using only a 2D encoder

Yanchun Xie, Yi Lian, Yang Jiang, Hailong Yu, Lei Wang
article en

Abstract

The demonstrated success of Vision-Language Models in 2D medical image analysis has motivated the extension of their capabilities to 3D volumetric data for tasks such as report generation and visual question answering. A primary obstacle to this advancement is the reliance of current approaches on specialized 3D vision encoders, whose performance is constrained by the scarcity of large-scale annotated datasets. This paper presents a data-efficient framework that bypasses the need for a 3D encoder, instead leveraging a pre-trained 2D vision encoder to process volumetric data. Our pipeline sequentially refines the visual representation. First, a cosine similarity strategy prunes redundant 2D slices to improve computational efficiency. Next, a spatial-frequency fusion module integrates spatial and frequency-domain information to model inter-slice correlations from the 2D features. Finally, a fine-grained feature injection mechanism mitigates information loss during feature compression by re-introducing high-resolution details into the final visual tokens for the Large Language Model. Evaluated on public 3D benchmarks, our framework demonstrates superior performance, achieving a METEOR score of 50.13 on M3D-Cap report generation and 82.90% accuracy on M3D-VQA, significantly outperforming previous models. Our work demonstrates a scalable and efficient paradigm for 3D medical vision-language tasks that avoids the need for 3D-specific pre-training, offering a data-efficient alternative to data-intensive 3D encoders.

Scientific ReportsVol. 16(1)
CCTEG Shenyang Research Institute (CN), General Hospital of Shenyang Military Region (CN), Wuhu Hit Robot Technology Research Institute (CN), Northeastern University (CN)
Openalex Percentile: Top 57%
Multimodal Machine Learning Applications
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A data-efficient 3D medical vision-language model using only a 2D encoder — Yanchun Xie, Yi Lian, et al. · Scientific Reports (2026) | TGRS Research Map | TGRS