Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification
This salt-modulated, heparin-free RT-QuIC platform enables sensitive tauopathy classification based on strain-specific kinetics and structure. It offers a practical tool for diagnostic development, mechanistic studies, and therapeutic screening.
Authors
- Michael A. Metrick (ORCID: https://orcid.org/0000-0002-9998-4630)
- Nicholas C. T. Gallagher
- B Ghetti
- Shunsuke Koga
- Pu Xu (ORCID: https://orcid.org/0000-0002-3785-7812)
- Byron Caughey
- Alessia Santambrogio
- Dennis W. Dickson
Institutions
- University of California, San Francisco (US)
- University of Cambridge (GB)
- Hospital of the University of Pennsylvania (US)
- Jacksonville College (US)
- California University of Pennsylvania (US)
- National Institute of Allergy and Infectious Diseases (US)
- Mayo Clinic in Florida (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71112
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- UK Research and Innovation
- Cambridge Trust
- National Institutes of Health
- School of Medicine, Indiana University
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research